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Updated: Feb 28, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition
Michel Nguyen1, Jean-Luc Stigliani, Genevieve Pratviel
1CNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse, France. colin.bonduelle@lcc-toulouse.fr.
Abstract:
Synthetic polypeptides are versatile polymers outstandingly relevant to prepare bioinspired materials. In this work, we present a new class of smart polypeptide polymers, called nucleopolypeptides, having lateral chains functionalized with thymidine nucleobases. Structural studies performed by circular dichroism have revealed that the secondary structure of the polymers was influenced by nucleotide interaction and DNA sequence variation affording a selective helix-to-beta sheet transition with oligo(AAAAA)6.
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