[Fibromyalgia : state of the issue in 2017]

Fibromyalgia (FM), whose diagnostic criteria were originally established in 1990 and updated in 2010, consists of a syndrome characterized by the presence of deep and diffuse musculoskeletal pain associated with other subjective manifestations (sleep, mood, cognitive problems). The prevalence is assessed in the general population at 2.2 %. Various risk factors were identified: age, gender, level of education and socio-economic status. Various etiological hypotheses have been explored, whether in neuroimaging or from the point of view of possible neuroendocrine and cytokine perturbations. In addition, various potential pathogenic mechanisms have been identified: genetic predisposition, central amplification, diffuse inhibitory control failure, muscle as peripheral nociceptive afferents. Finally, with regard to treatment and clinical course, the first will be multidisciplinary and the second will not be marked by real remission. In addition, patients tend to reduce their activities (professional, physical or leisure), which degrades and perpetuates the situation, while they must remain as active as possible.