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Updated: Feb 28, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

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Autosomal dominant polycystic kidney disease and the heart and brain

Vinod Krishnappa1, Poornima Vinod2, Divya Deverakonda3

  • 1Department of Nephrology, Cleveland Clinic Akron General/Akron Nephrology Associates, Akron, OH, USA.

Cleveland Clinic Journal of Medicine
|June 20, 2017
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) involves systemic issues like hypertension and cardiac problems. This review covers ADPKD complications, their causes, and updated management strategies.

Area of Science:

  • Nephrology
  • Cardiology
  • Neurology

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder with widespread systemic effects.
  • Key complications include hypertension, cardiac issues, and intracranial aneurysms.

Purpose of the Study:

  • To provide an overview of major systemic manifestations in ADPKD.
  • To discuss the pathophysiology and current management of hypertension, cardiac complications, and intracranial aneurysms in ADPKD patients.

Main Methods:

  • Literature review of recent developments in ADPKD management.
  • Synthesis of information on pathophysiology and clinical manifestations.

Main Results:

  • Hypertension is a common and early complication in ADPKD, contributing to disease progression.
  • Cardiac complications, such as left ventricular hypertrophy, are prevalent in ADPKD.
  • Intracranial aneurysms represent a significant risk, necessitating screening and management.

Conclusions:

  • Comprehensive management of ADPKD requires addressing systemic complications.
  • Advances in understanding pathophysiology are leading to improved therapeutic strategies.
  • Multidisciplinary care is essential for optimizing outcomes in ADPKD patients.

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