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Cardiopulmonary involvement in Takayasu's arteritis
David N Brennan1, Kenneth J Warrington2, Cynthia S Crowson3
1Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. brennan.david1@mayo.edu.
Clinical and Experimental Rheumatology
|June 20, 2017
Summary
Cardiopulmonary abnormalities are common in Takayasu
Area of Science:
- Rheumatology
- Cardiology
- Pulmonology
Background:
- Takayasu's arteritis (TAK) is a rare, chronic inflammatory disease affecting large arteries.
- Cardiopulmonary (CP) involvement can occur but its impact on disease outcomes requires further evaluation.
Purpose of the Study:
- To investigate the prevalence of cardiopulmonary involvement in patients diagnosed with Takayasu's arteritis.
- To assess the association between CP involvement and key disease outcomes, including surgery risk and mortality.
Main Methods:
- Retrospective cohort study of 124 patients with newly diagnosed TAK (1984-2009).
- Review of medical records, angiograms, and cardiac studies for CP abnormalities.
- Cox proportional hazards models used to analyze outcomes associated with CP involvement.
Main Results:
- 36% of TAK patients exhibited objective CP abnormalities within 6 months of diagnosis.
- Pulmonary hypertension (PH) significantly increased the risk of first surgery (HR 12.9).
- Overall CP involvement did not correlate with increased risk of surgery or mortality.
Conclusions:
- Cardiopulmonary abnormalities are frequently observed at the initial presentation of Takayasu's arteritis.
- Pulmonary hypertension is a critical predictor of increased surgical risk in TAK patients.
- In this cohort, CP involvement did not significantly impact overall mortality.
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