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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

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Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
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Bone resection for facial cutaneous malignancies.

Markus Brunner1,2, Sydney Ch'ng1, Kerwin Shannon1

  • 1Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.

Journal of Surgical Oncology
|June 20, 2017
PubMed
Summary
This summary is machine-generated.

Bone resection is a viable treatment for advanced facial and scalp skin cancers. However, brain invasion and positive surgical margins significantly decrease patient survival, highlighting the importance of complete tumor removal in craniofacial cutaneous malignancy.

Keywords:
cSCCcutaneousheadsquamous

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Cutaneous malignancies of the face and scalp can invade underlying bone and soft tissues.
  • Surgical resection is a primary treatment modality for these advanced cancers.
  • Understanding clinical outcomes and prognostic factors is crucial for patient management.

Purpose of the Study:

  • To analyze clinical outcomes of patients undergoing bone resection for craniofacial cutaneous malignancy.
  • To identify risk factors associated with disease progression and reduced survival.
  • To evaluate the accuracy of pre-operative imaging in predicting tumor infiltration.

Main Methods:

  • Retrospective collection of data from 62 patients over 10 years.
  • Analysis of risk factors for disease progression.
  • Assessment of computed tomography (CT) and magnetic resonance imaging (MRI) for predicting bone, dura, and brain infiltration.

Main Results:

  • Brain invasion, positive surgical margins, and dural margin involvement significantly reduced survival.
  • CT and MRI demonstrated high accuracy (88-89%) in predicting bone infiltration.
  • MRI accurately predicted dural invasion in 89% of cases but underestimated extent in 23%.

Conclusions:

  • Bone resection is a reasonable surgical option for advanced cutaneous malignancies of the face and scalp.
  • Preventing brain invasion and achieving clear surgical margins are critical for improving survival.
  • Pre-operative imaging is valuable but has limitations in assessing the full extent of dural invasion.