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Updated: Feb 28, 2026

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture
Published on: February 4, 2018
An algorithm for filtering detector instabilities in search of novel non-exponential decay and in conventional
G W Hitt1, B Goddard2, A A Solodov2
1Department of Applied Mathematics & Sciences, Khalifa University of Science, Technology and Research, P. O. Box 127788 Abu Dhabi, UAE; Department of Nuclear Engineering, Khalifa University of Science, Technology and Research, P. O. Box 127788 Abu Dhabi, UAE.
Abstract:
Recent reports of Solar modulation of beta-decay have reignited interest in whether or not radioactive half-lives are constants. A numerical approach for filtering instrumental effects on residuals is developed, using correlations with atmospheric conditions recorded while counting 204Tl emissions with a Geiger-Müller counter. Half-life oscillations and detection efficiency oscillations can be separated provided their periods are substantially different. A partial uncertainty budget for the 204Tl half-life shows significant decreases to medium-frequency instabilities correlated with pressure and temperature, which suggests that further development may aid general improvements in half-life determinations.
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