Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon induction: a conformational hypothesis.

D L Miles, D W Miles, H Eyring

    Proceedings of the National Academy of Sciences of the United States of America
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Screening Criteria in Breast Cancer Trials: Are They Too Restrictive?

    Clinical oncology (Royal College of Radiologists (Great Britain))·2015
    Same author

    Molecular mechanisms in inflammation and stress.

    Science in progress·2014
    Same author

    First-line bevacizumab in combination with chemotherapy for HER2-negative metastatic breast cancer: pooled and subgroup analyses of data from 2447 patients.

    Annals of oncology : official journal of the European Society for Medical Oncology·2013
    Same author

    Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer.

    British journal of cancer·2013
    Same author

    Randomized phase II non-inferiority study (NO16853) of two different doses of capecitabine in combination with docetaxel for locally advanced/metastatic breast cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2011
    Same author

    The efficiency of a high-speed screening procedure in detecting the neuropsychiatrically unfit at a U.S. Marine Corps recruit training depot.

    The Journal of psychology·2010
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Polynucleotides like poly(I)•poly(C) induce interferon when their glycosidic orientations are stable. Minor instability in specific conformational regions reduces their potency for interferon induction.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Immunology

    Background:

    • Polynucleotides, such as poly(I)•poly(C), are known to induce interferon production.
    • The precise structural requirements for this induction are not fully understood.

    Purpose of the Study:

    • To investigate the role of polynucleotide conformation in interferon induction.
    • To identify specific glycosidic orientations essential for interferon-inducing activity.

    Main Methods:

    • Conformational energy calculations were performed for various purine nucleoside analogs.
    • Analysis focused on glycoside rotational profiles and the impact of removing the 2'-OH group.

    Main Results:

    • A conformational triad of stable regions (near 20°, 80°, 160°) is proposed as necessary for interferon induction.

    Related Experiment Videos

  • Slight instability (1-3 kcal/mole) in these regions significantly reduces polynucleotide potency.

    • Conclusions:

    • Specific, stable glycosidic orientations are critical for polynucleotides to induce interferon.
    • This conformational stability likely confers the necessary flexibility and activity for immune response modulation.