Related Experiment Video

Updated: Feb 28, 2026

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.6K

Role of SOCE architects STIM and Orai proteins in Cell Death

Jyoti Tanwar1, Rajender K Motiani1

  • 1Systems Biology Group, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110025, India.

Cell Calcium
|June 21, 2017
PubMed

Insights

Calcium (Ca2+) signaling regulates cell functions. Stromal interaction molecules (STIM) and Orai channels control cell fate, influencing survival and death pathways.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Calcium (Ca2+) signaling is crucial for cellular functions like survival, proliferation, and migration.
  • Disruptions in cellular Ca2+ homeostasis can trigger cell death via autophagy or apoptosis.
  • The endoplasmic reticulum (ER) is a primary Ca2+ store, releasing Ca2+ through IP3 receptors (IP3R).

Purpose of the Study:

  • To review the role of STIM and Orai proteins in regulating cell death signaling.
  • To explore the dual functions of STIM and Orai proteins in cell fate decisions.

Main Methods:

  • Literature review of studies on STIM and Orai homologs.
  • Analysis of Ca2+ signaling pathways involving STIM and Orai.

Main Results:

  • STIM proteins sense ER Ca2+ depletion and activate Orai channels.
  • STIM1, STIM2, Orai1, and Orai3 are implicated in regulating cell survival and death.
  • Emerging evidence highlights the critical role of these proteins in cell death signaling.

Conclusions:

  • STIM and Orai proteins play a significant role in modulating cell death.
  • Understanding their dual role is key to deciphering cell fate decisions in various cellular contexts.
Keywords:
ApoptosisAutophagyCell survivalOrai1Orai3STIM1

More Related Videos

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry05:29

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry

Published on: March 24, 2023

5.7K
Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

18.7K

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
10.6K
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
14.4K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.9K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
9.0K
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
16.2K
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.8K