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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Improving IV Insulin Administration in a Community Hospital
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Clinical practice points for diabetes management during RAMADAN fast.

Shaukat Sadikot1, K Jothydev2, A H Zargar3

  • 1International Diabetes Federation, Executive Board Member - International Atherosclerosis Association, Consultant at Jaslok Hospital and Research, Centre, Mumbai, India.

Diabetes & Metabolic Syndrome
|June 21, 2017
PubMed
Summary

Managing type 2 diabetes during Ramadan requires careful attention. Gliclazide is an effective and safe medication option for individuals with type 2 diabetes who are fasting during Ramadan.

Keywords:
Diabetes managementGliclazideRamadan fasting

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Clinical Pharmacy

Background:

  • Diabetes mellitus poses significant risks during Ramadan fasting, including hypoglycemia and mortality.
  • Standard diabetes management protocols are insufficient for fasting patients, presenting challenges for healthcare providers.

Purpose of the Study:

  • To review clinical trials and studies on antidiabetic agents for patients fasting during Ramadan.
  • To evaluate the safety and efficacy of various antidiabetic medications in the context of Ramadan.

Main Methods:

  • Literature review of clinical trials and studies.
  • Analysis of antidiabetic agents used in Ramadan fasting patients.

Main Results:

  • Gliclazide demonstrated effectiveness in managing type 2 diabetes during Ramadan.
  • Evidence suggests gliclazide can be safely recommended for type 2 diabetic patients fasting during Ramadan.

Conclusions:

  • Gliclazide is a suitable therapeutic option for type 2 diabetes management during Ramadan.
  • Healthcare practitioners can consider gliclazide for patients observing Ramadan fasts.