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Characterization and risk factors for aortic dilatation in pediatric patients with bicuspid aortic valve

Anna Sabaté-Rotés1, Laura Sabidó Sanchez1, Ferran Gran Ipiña1

  • 1Cardiología Pediátrica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Medicina Clinica
|June 21, 2017
PubMed

Insights

Pediatric patients with bicuspid aortic valve often experience aortic dilatation, particularly of the ascending aorta. Early medical follow-up is crucial for managing this common valve impairment.

Area of Science:

  • Cardiovascular Medicine
  • Pediatric Cardiology
  • Medical Genetics

Background:

  • Bicuspid aortic valve (BAV) is a common congenital heart defect associated with aortic dilatation, a significant cause of morbidity and mortality.
  • Ascending aortic dilatation in adults with BAV is well-documented, but pediatric involvement requires further characterization.

Purpose of the Study:

  • To identify the prevalence and characteristics of aortic involvement in pediatric patients with BAV.
  • To determine risk factors associated with aortic dilatation in this population.

Main Methods:

  • Retrospective analysis of aortic measurements in pediatric patients with BAV from 1997-2015.
  • Exclusion of patients with syndromic aortic dilatation.

Main Results:

  • Aortic dilatation (z-score>2) was observed in over one-third of 206 pediatric BAV patients.
  • Ascending aorta was primarily affected (70/80 patients), with the aortic root often spared.
  • Absence of coarctation and a vertical valve opening pattern were associated with ascending aorta dilatation.

Conclusions:

  • Pediatric patients with BAV frequently exhibit aortic dilatation, particularly of the ascending aorta.
  • Regular medical follow-up is essential for early detection and management of aortic abnormalities in these children.
  • Identifying risk factors like valve opening pattern can aid in risk stratification.
Abstract

Keywords:
Aneurisma aórticoAortic aneurysmBicuspid aortic valveCongenital heart diseaseDilataciónDilatationEnfermedad cardiaca congénitaPediatricsPediatríaSenos de ValsalvaSinus of ValsalvaVálvula aórtica bicúspide

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