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Related Concept Videos

Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
454
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

391
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
391
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

284
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
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Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

577
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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Reply to Comment on "Clazakizumab in the treatment of chronic active antibody-mediated kidney transplant rejection: Results from the IMAGINE phase 3, randomized, double-blind, placebo-controlled study".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
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Microvascular Inflammation in Kidney Transplantation.

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Declining All-cause Allograft Survival in the Modern era: A 50-y Single-center Consecutive Cohort Study.

Transplantation·2026
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Clazakizumab in the treatment of chronic active antibody-mediated kidney transplant rejection: Results from the IMAGINE phase 3, randomized, double-blind, placebo-controlled study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
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Education Intervention for Evaluation and Living Donor Kidney Transplantation: A randomized trial.

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Related Experiment Video

Updated: Feb 28, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Understanding Medication Nonadherence after Kidney Transplant.

Thomas E Nevins1, Peter W Nickerson2, Mary Amanda Dew3

  • 1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Journal of the American Society of Nephrology : JASN
|June 21, 2017
PubMed
Summary
This summary is machine-generated.

Medication nonadherence is a major barrier to long-term kidney transplant survival. Identifying and addressing individual patient barriers is crucial for improving immunosuppression and graft outcomes.

Keywords:
rejectionrenal transplantationtransplant outcomes

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Area of Science:

  • Nephrology
  • Immunology
  • Transplantation Medicine

Background:

  • Alloimmunity necessitates lifelong immunosuppression post-renal transplant, impacting graft survival.
  • Medication nonadherence is a significant barrier to effective immunosuppression.
  • Nonadherence often emerges early post-transplant, despite a delayed clinical effect.

Purpose of the Study:

  • To review the multifaceted etiology of medication nonadherence in renal transplant recipients.
  • To identify key risk factors associated with nonadherence.
  • To highlight the need for tailored interventions to improve adherence and graft survival.

Main Methods:

  • Review of literature on medication nonadherence in renal transplant recipients.
  • Analysis of risk factors identified in previous studies.
  • Synthesis of findings from qualitative systematic reviews on intervention strategies.

Main Results:

  • Strongest risk factors for nonadherence include prior nonadherence and young age (adolescents/young adults).
  • Minority race/ethnicity, poor social support, and perceived poor health are also significant risk factors.
  • In pediatric populations, psychologic, behavioral, and parental factors are important.

Conclusions:

  • Effective solutions for medication nonadherence are essential for achieving the goal of "one transplant for life."
  • Interventions must be individualized, addressing unique patient needs, motivations, and barriers.
  • Further research with adequately powered studies is needed to evaluate intervention efficacy.