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Association between HMGB1 and asthma: a literature review
Egidio Imbalzano1, Sebastiano Quartuccio1, Eleonora Di Salvo2
1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Background:
Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation.
Objective:
This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma.
Methods:
We reviewed experimental studies that investigated the pathogenetic role of HMGB in bronchial airway hyper-responsiveness, inflammation and the correlation between HMGB1 level and asthma.
Results:
A total of 19 studies assessing the association between HMGB1 and asthma were identified.
Conclusions:
What emerged from this literature review was the confirmation of HMGB-1 involvement in diseases characterised by chronic inflammation, especially in pulmonary pathologies. Findings reported suggest a potential role of the alarmin in being a stadiation method and a marker of therapeutic efficacy; finally, inhibiting HMGB1 in humans in order to contrast inflammation should be the aim for future further studies.
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