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Amisulpride withdrawal dyskinesia: a case report.

Yu-Chi Lo1, Ying-Chieh Peng2

  • 1Ministry of Health and Welfare Kinmen Hospital, No. 2, Fuxing Rd., Jinhu Township, Kinmen County, 89142 Taiwan.

Annals of General Psychiatry
|June 21, 2017
PubMed
Summary

Antipsychotic drug withdrawal, particularly amisulpride, can cause withdrawal dyskinesia. Prompt identification and intervention are crucial to manage these abnormal involuntary movements and prevent persistent tardive dyskinesia.

Keywords:
Abnormal involuntary movementAmisulprideAntipsychoticsCase reportDyskinesiaSchizophreniaSide effectsWithdrawal

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Antipsychotic drug withdrawal effects are understudied.
  • Limited research exists on amisulpride withdrawal dyskinesia.

Observation:

  • A 63-year-old male with schizophrenia experienced severe withdrawal dyskinesia, dystonia, and akathisia after amisulpride dosage reduction.
  • Symptoms improved upon increasing the amisulpride dosage.

Findings:

  • Dosage reduction or abrupt cessation of amisulpride can precipitate withdrawal dyskinesia.
  • Withdrawal-emergent dyskinesia may evolve into persistent tardive dyskinesia.

Implications:

  • Early identification of withdrawal-emergent dyskinesia is essential.
  • Prompt medical intervention can manage abnormal involuntary movements.
  • Understanding amisulpride withdrawal is critical for patient care.