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Updated: Feb 28, 2026

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
Published on: July 9, 2016
Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and
Keren K Griffiths1, Richard J Levy1
1Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA.
Abstract:
Autism spectrum disorder (ASD), the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as restricted and repetitive behavior. The underlying cause of autism is unknown and therapy is currently limited to targeting behavioral abnormalities. Emerging studies suggest a link between mitochondrial dysfunction and ASD. Here, we review the evidence demonstrating this potential connection. We focus specifically on biochemical links, genetic-based associations, non-energy related mechanisms, and novel therapeutic strategies.
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