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Related Experiment Video

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Ultrasonic Assessment of Myocardial Microstructure
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Non-invasive coronary wave intensity analysis.

Christopher J Broyd1,2, Fausto Rigo3, Justin Davies4

  • 1Imperial College London, London, UK. chrisbroyd@yahoo.co.uk.

The International Journal of Cardiovascular Imaging
|June 21, 2017
PubMed
Summary

Wave intensity analysis, a tool for studying blood flow, can now be non-invasively measured. This advancement in calculating the backward decompression wave may bring this research tool into clinical practice.

Keywords:
Coronary physiologyMicrocirculationWave intensity analysis

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Area of Science:

  • Cardiovascular Physiology
  • Hemodynamics
  • Biomedical Engineering

Background:

  • Wave intensity analysis quantifies energy exchange driving blood flow.
  • The backward decompression wave in coronary circulation is crucial but invasively measured.
  • Previous limitations hindered widespread clinical application of wave intensity analysis.

Purpose of the Study:

  • To introduce a non-invasive method for wave intensity analysis.
  • To enable calculation of the backward decompression wave without invasive procedures.
  • To facilitate the clinical adoption of wave intensity analysis.

Main Methods:

  • Utilizing transthoracic echocardiography to obtain coronary flow velocity waveforms.
  • Employing established measures of central aortic pressure for pressure waveforms.
  • Calculating coronary wave intensity analysis from non-invasively acquired data.

Main Results:

  • Successfully developed a non-invasive approach for wave intensity analysis.
  • Enabled the calculation of the backward decompression wave using non-invasive techniques.
  • Demonstrated the feasibility of applying this tool outside of invasive research settings.

Conclusions:

  • Non-invasive wave intensity analysis is now feasible.
  • This method allows for the calculation of the backward decompression wave.
  • The technique is poised for broader application, potentially transitioning to clinical use.