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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Feb 28, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Optical coherence tomography angiography in pre-perimetric open-angle glaucoma.

Gilda Cennamo1, Daniela Montorio2, Nunzio Velotti2

  • 1Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy. xgilda@hotmail.com.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|June 21, 2017
PubMed
Summary

Optical coherence tomography (OCT) angiography detects microvascular changes in pre-perimetric open-angle glaucoma. This method aids in early diagnosis and monitoring of the condition.

Keywords:
OCT angiographyOpen-angle glaucomaSD-OCTVisual field

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Open-angle glaucoma is a leading cause of irreversible blindness.
  • Early detection of glaucoma is crucial for effective management and preventing vision loss.
  • Pre-perimetric glaucoma presents diagnostic challenges with traditional methods.

Purpose of the Study:

  • To assess the diagnostic performance of optical coherence tomography (OCT) angiography in identifying early-stage open-angle glaucoma.
  • To compare OCT angiography findings with spectral-domain OCT and visual field parameters.
  • To evaluate the utility of OCT angiography for microvascular assessment in glaucoma.

Main Methods:

  • A prospective study involving 26 patients with pre-perimetric open-angle glaucoma and 32 healthy controls.
  • Evaluation of OCT angiography, spectral-domain OCT, and visual field parameters.
  • Analysis of differences between patient and control groups, and correlation with traditional glaucoma metrics.

Main Results:

  • Significantly lower flow index and vessel density were observed in pre-perimetric glaucoma eyes compared to normal eyes (p=0.021 and p=0.001, respectively).
  • Ganglion cell complex parameters showed significant correlation with OCT angiography findings (p<0.05).
  • Retinal nerve fiber layer and visual field parameters did not correlate with OCT angiography results.

Conclusions:

  • OCT angiography is a reliable and user-friendly technique for evaluating optic nerve head microvascular changes.
  • This imaging modality shows promise for the early diagnosis and ongoing management of glaucoma.
  • OCT angiography offers a valuable tool for detecting subtle vascular alterations in glaucoma patients.