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Updated: Feb 28, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Advantages and disadvantages of using intravenous tissue Plasminogen activator as salvage therapy for inoperable
Robyn Basken1, Charles M Bazzell2, Richard Smith3
1Department of Pharmacy, Banner University Medical Center Tucson, Tucson, Arizona.
Abstract:
Device thrombosis is a devastating complication of left ventricular assist devices. The definitive treatment has been device exchange or explant. Evidence of increasing morbidity and mortality with device exchange has shifted strategies toward conservative management. In this report, we detail the use of thrombolytics as salvage therapy in a patient with an occlusive HeartWare ventricular assist device (HeartWare Inc., Framingham, MA) thrombus, resulting in long-term survival without further intervention.
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