Related Experiment Video

Updated: Feb 28, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K

[Hepatitis C virus-associated cryoglobulinemic vasculitis: A 20-year experience with treatment]

T M Ignatova1, L V Kozlovskaya2, N B Gordovskaya2

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

Terapevticheskii Arkhiv
|June 21, 2017
PubMed

Insights

Antiviral therapy (AVT) is the preferred treatment for hepatitis C virus (HCV)-associated cryoglobulinemic vasculitis (CV). For severe cases, combining AVT with rituximab offers the best outcomes for patients with HCV-associated CV.

Area of Science:

  • Hepatology
  • Rheumatology
  • Immunology

Background:

  • Hepatitis C virus (HCV)-associated cryoglobulinemic vasculitis (CV) is a serious condition impacting patient prognosis.
  • Understanding treatment efficacy is crucial for managing this complex autoimmune manifestation.

Purpose of the Study:

  • To evaluate the treatment experience of a multidisciplinary hospital for HCV-associated CV.
  • To compare the effectiveness of different therapeutic strategies, including antiviral therapy (AVT) and immunosuppressive therapy (IST).

Main Methods:

  • Retrospective analysis of 72 patients with HCV-associated CV.
  • Assessment of traditional IST (corticosteroids ± cyclophosphamide), rituximab, and AVT.
  • Vasculitis activity measured by Birmingham vasculitis activity score (BVAS); survival and prognostic factors analyzed.

Main Results:

  • Antiviral therapy (AVT) achieved clinical remission in 68% of patients and showed long-term advantages over IST.
  • Rituximab was more effective than traditional IST (73% vs. 13% remission).
  • Combined AVT and rituximab demonstrated highest efficacy in severe CV cases; factors like age >55, liver cirrhosis, and renal failure adversely affected prognosis.

Conclusions:

  • Antiviral therapy (AVT) is the primary treatment for HCV-associated CV.
  • Combination therapy with AVT and rituximab is recommended for severe CV presentations.
  • HCV-associated CV significantly influences the prognosis of chronic HCV infection.
Abstract

Keywords:
antiviral therapycryoglobulinemic vasculitishepatitis C virusinterferon-αrituximab

More Related Videos

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.9K
Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells09:18

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells

Published on: September 7, 2018

81.9K

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
279
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
435
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
748
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
398
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
436