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Updated: Feb 28, 2026

Characterization of a Novel Human Organotypic Retinal Culture Technique
Published on: June 9, 2021
Correlation between Interleukin-6 and Thrombin-Antithrombin III Complex Levels in Retinal Diseases
Rita Ehrlich1,2, Alon Zahavi1,2, Ruth Axer-Siegel1,2
1a Department of Ophthalmology , Rabin Medical Center , Petach Tikva , Israel.
Purpose:
This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies.
Methods:
Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups.
Results:
A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups (P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies.
Conclusion:
Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood-retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.
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