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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolomics as a Driver in Advancing Precision Medicine in Sepsis
Michelle Eckerle1, Lilliam Ambroggio2,3, Michael A Puskarich4
1Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Pharmacotherapy
|June 21, 2017
Summary
Metabolomics offers detailed insights into sepsis pathophysiology and treatment, surpassing other systems biology methods. Further validation is needed to translate these discoveries into clinical practice for sepsis diagnosis and therapy.
Area of Science:
- Metabolomics as a systems biology approach.
- Focus on endogenous small molecules (metabolites).
Background:
- Sepsis is a complex disease state.
- Current diagnostic and treatment strategies require enhancement.
Purpose of the Study:
- To explain the science of metabolomics.
- To review metabolomics applications in sepsis diagnosis and treatment.
- To explore metabolomics' role in precision medicine for sepsis.
Main Methods:
- Nonsystematic literature review.
- Focus on metabolomics, pharmacometabolomics, and sepsis.
- Inclusion of human (adult and pediatric) and animal studies.
Main Results:
- Metabolomics provides detailed insights into sepsis pathophysiology, biochemical pathways, and differences between survivors and non-survivors.
- It surpasses genomics, transcriptomics, and proteomics in biochemical detail for sepsis.
- Pharmacometabolomics can help differentiate drug responders and non-responders in sepsis treatment.
Conclusions:
- Metabolomics is a viable tool for sepsis research, offering greater biochemical insight than other systems biology approaches.
- Clinical application of metabolomics in sepsis is not yet fully realized.
- Prospective validation studies are necessary to translate metabolomic discoveries into clinical utility for sepsis.
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