Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.2K
Cancer02:18

Cancer

55.0K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy.

Nature cell biology·2026
Same author

Tumour-host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment.

Molecular oncology·2026
Same author

EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Cell reports methods·2025
Same author

Autophagy regulation by signaling.

Current opinion in cell biology·2025
Same author

NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.

PLoS biology·2025
Same author

EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions <i>in Drosophila melanogaster</i>.

bioRxiv : the preprint server for biology·2024
Same journal

Tegument protein UL16 of herpes simplex virus 1 suppresses the innate immune response by downregulating MAVS abundance via mitophagy.

Autophagy·2026
Same journal

AARS2-mediated lactylation of ULK1 promotes autophagy-dependent progression of clear cell renal cell carcinoma.

Autophagy·2026
Same journal

Mechanistic studies of autophagic cargo recruitment and membrane shaping through in vitro reconstitution.

Autophagy·2026
Same journal

Receptor-cargo coupling during ER-autophagy depends on coat proteins and ER membrane properties.

Autophagy·2026
Same journal

Translation control of autophagy genes modulates cellular response to hydroxyurea-induced genotoxic stress.

Autophagy·2026
Same journal

RAPSN/rapsyn aggregation-induced HSPA/HSP70-BAG3 aggrephagy maintains CHRN integrity in myasthenia gravis.

Autophagy·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.9K

Microenvironment and tumors-a nurturing relationship.

Nadja Sandra Katheder1,2, Tor Erik Rusten1,2

  • 1a Department of Molecular Cell Biology , Institute for Cancer Research, Oslo University Hospital , Montebello , Oslo , Norway.

Autophagy
|June 21, 2017
PubMed
Summary
This summary is machine-generated.

Cancer cells hijack autophagy in neighboring cells to fuel their growth. This study reveals that inhibiting autophagy in the tumor microenvironment can reduce cancer progression, highlighting a novel therapeutic target.

Keywords:
DrosophilaJNKamino acid transporterautophagyhippointerleukin-6microenvironmentrasscribble

More Related Videos

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

8.2K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.5K

Related Experiment Videos

Last Updated: Feb 28, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.9K
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

8.2K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.5K

Area of Science:

  • Cellular Biology
  • Oncology
  • Developmental Biology

Background:

  • Autophagy, a cellular recycling process, is linked to cancer but primarily studied within tumor cells.
  • The role of autophagy in the tumor microenvironment and its non-cell-autonomous functions remain largely unexplored.

Purpose of the Study:

  • To investigate the role of autophagy in non-transformed neighboring cells during tumor development.
  • To elucidate the mechanisms by which tumor cells influence autophagy in their microenvironment.
  • To assess the therapeutic potential of targeting microenvironmental autophagy.

Main Methods:

  • Utilized a Drosophila in vivo tumor model to study autophagy.
  • Employed pharmacological inhibition and genetic ablation of autophagy in the tumor microenvironment.
  • Investigated signaling pathways (TNFα-JNK-IL-6) and metabolic coupling between tumor and neighboring cells.

Main Results:

  • Autophagy is upregulated in neighboring epithelial cells and distal tissues in the presence of tumors.
  • Inhibiting autophagy in the microenvironment significantly reduces tumor growth.
  • Tumor cells induce microenvironmental autophagy via a TNFα-JNK-IL-6 cascade, relying on neighboring cells for essential amino acids.
  • Autophagy-deficient tumors regain growth capacity when transplanted into an autophagy-competent host.

Conclusions:

  • Autophagy in the tumor microenvironment plays a crucial, tumor-promoting role.
  • Cancer cells actively manipulate neighboring cells' autophagy to support their own proliferation.
  • Targeting microenvironmental autophagy presents a promising strategy for cancer therapy.