Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

1.6K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.6K
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

4.2K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
4.2K
Fetal Circulation01:14

Fetal Circulation

3.7K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.7K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

7.0K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
7.0K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

75.1K
Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
75.1K
Embryonic Stem Cells00:58

Embryonic Stem Cells

33.0K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
33.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity.

Cell reports·2026
Same author

Identification of a lipid oxygen radical defense pathway and its epigenetic control.

Nature communications·2025
Same author

Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation.

Current opinion in genetics & development·2025
Same author

The 'mono-side' of cutaneous adverse drug reactions.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Evolutionarily recent transcription factors partake in human cell cycle regulation.

Cell genomics·2025
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.8K

A KRABsody for Embryo-Placental Development.

Didier Trono1

  • 1School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Developmental Cell
|June 21, 2017
PubMed
Summary
This summary is machine-generated.

Zinc finger protein ZFP568 regulates Insulin-like Growth Factor 2 (Igf2) expression. This zinc finger protein is crucial for proper embryonic and placental development in mice.

More Related Videos

Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues
04:17

Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues

Published on: September 8, 2023

2.1K
Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

10.6K

Related Experiment Videos

Last Updated: Feb 28, 2026

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.8K
Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues
04:17

Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues

Published on: September 8, 2023

2.1K
Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

10.6K

Area of Science:

  • Genetics
  • Developmental Biology
  • Molecular Biology

Background:

  • Hundreds of KRAB zinc finger proteins exist in humans and mice.
  • These proteins are involved in regulating transposable elements.
  • The specific roles of many of these proteins remain unclear.

Purpose of the Study:

  • To investigate the function of the murine zinc finger protein ZFP568.
  • To understand the role of ZFP568 in embryonic and placental development.
  • To identify the downstream targets regulated by ZFP568.

Main Methods:

  • Utilized mouse models to study ZFP568 function.
  • Analyzed gene expression patterns, specifically focusing on Igf2.
  • Investigated the impact of ZFP568 on embryonic and placental development.

Main Results:

  • ZFP568 was identified as a key regulator of Igf2 expression in mice.
  • Loss of ZFP568 function led to developmental defects.
  • The study highlights ZFP568's critical role in embryonic and placental growth.

Conclusions:

  • ZFP568 is essential for normal embryonic and placental development.
  • Regulation of Igf2 by ZFP568 is a critical pathway for development.
  • This research sheds light on the function of KRAB zinc finger proteins in mammalian development.