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Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body
Ron Korstanje1, Jennifer L Ryan1, Holly S Savage1
1The Jackson Laboratory, Bar Harbor, Maine 04609.
Endocrinology
|June 22, 2017
Summary
Wireless telemetry in mice revealed nocturnal hyperglycemia days before diurnal changes, showing a link between high blood glucose and declining body temperature during diabetes development.
Area of Science:
- Endocrinology
- Metabolic Research
- Animal Models of Disease
Background:
- Continuous glucose monitoring (CGM) in mice is often limited in duration.
- Existing methods can impact mouse behavior and measurement accuracy due to physical tethering.
Purpose of the Study:
- To investigate the high-resolution circadian rhythms of blood glucose and body temperature in mice over 12 weeks.
- To characterize the real-time onset of hyperglycemic development using wireless telemetry.
- To establish a more translatable model for diabetes research.
Main Methods:
- Utilized wireless telemetry to measure blood glucose and body temperature at 10-second intervals for 12 weeks.
- Employed a cohort of NOD/ShiLtJ female mice.
- Focused on obtaining high-resolution, real-time data without physical tethering.
Main Results:
- Identified elevated nocturnal glucose concentrations preceding diurnal elevations, reaching diabetic ranges days earlier.
- Observed a strong negative correlation between high blood glucose and body temperature.
- Documented a steady decline in body temperature correlating with diabetes progression.
Conclusions:
- Wireless telemetry offers improved resolution for studying diabetes progression in mouse models.
- Nocturnal hyperglycemia is an early indicator of diabetes onset in this model.
- Body temperature decline is a potential biomarker for diabetes development in mice.
