Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Matrix Stiffness Induces Endothelial Network Senescence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling.

Nature biomedical engineering·2026

Same author

Corrigendum to 'Concentration-dependent transfer and phytotoxicity of iodine and rhenium in lettuce (Lactuca sativa L.) with implications for nuclear waste risk assessment' [Environ. Pollut. 404 (2026) 128478].

Environmental pollution (Barking, Essex : 1987)·2026

Same author

Concentration-dependent transfer and phytotoxicity of iodine and rhenium in lettuce (Lactuca sativa L.) with implications for nuclear waste risk assessment.

Environmental pollution (Barking, Essex : 1987)·2026

Same author

PathwayEmbed: a computational tool to quantify intracellular signaling transduction states from transcriptomic data.

Bioinformatics (Oxford, England)·2026

Same author

Thermosensitive Hydrogel Enables Noninvasive Extracellular Vesicle Therapy for Atopic Dermatitis.

Biomaterials research·2026

Same journal

Physics-Informed Machine Learning in Biomedical Science and Engineering.

Annual review of biomedical engineering·2026

Same journal

Advancements and Challenges in Computer-Assisted Medical Interventions for Image-Guided Prostate Cancer Treatments.

Annual review of biomedical engineering·2026

Same journal

Recent Advances in mRNA Therapeutic Cancer Vaccines.

Annual review of biomedical engineering·2026

Same journal

Artificial Intelligence-Based Analysis of Laparoscopic Imaging for Intraoperative Surgical Decision Support.

Annual review of biomedical engineering·2026

Same journal

Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.

Annual review of biomedical engineering·2026

Same journal

Digital Twins for Biofluids.

Annual review of biomedical engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Bioinspired Hydrogels to Engineer Cancer Microenvironments.

Kyung Min Park^1,2, Daniel Lewis¹, Sharon Gerecht^1,3

¹Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218;

Annual Review of Biomedical Engineering

|June 22, 2017

Summary

This summary is machine-generated.

Engineered tumor models using hydrogels mimic the tumor microenvironment, aiding cancer research and drug screening. These advanced models accelerate the development of new cancer therapies.

Keywords:

cancer research engineered tumor models polymeric hydrogels tumor microenvironments

More Related Videos

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Related Experiment Videos

Last Updated: Feb 28, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Area of Science:

Biomaterials Science
Cancer Biology
Biotechnology

Background:

Tumor microenvironments significantly influence cancer progression and metastasis.
Key factors include extracellular matrix (ECM) composition, oxygen levels, pH, and stiffness.
Current research focuses on creating advanced 3D tumor models.

Purpose of the Study:

To review the development and application of polymeric hydrogels for engineering tumor microenvironments.
To highlight advancements in cancer engineering using these models.
To discuss their potential for accelerating therapeutic development.

Main Methods:

Utilizing bioinspired hydrogels to create 3D tumor models.
Engineering native tumor extracellular matrix (ECM) components.
Focusing on materials science and cancer engineering approaches.

Main Results:

Engineered hydrogel models accurately recapitulate native tumor microenvironments.
These models serve as promising platforms for cancer biology studies.
They are valuable for screening therapeutic agents.

Conclusions:

Polymeric hydrogels are crucial for developing sophisticated tumor models.
Engineered tumor models offer significant potential for cancer research.
Advancements in this field can accelerate clinical outcomes and improve cancer treatment.