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Evaluation of P16 expression in canine appendicular osteosarcoma
B G Murphy1, M Y Mok2, D York3
1Department Pathology, University of California, Davis, School of Veterinary Medicine, Microbiology and Immunology, Davis, CA, 95618, USA. bmurphy@ucdavis.edu.
BMC Veterinary Research
|June 22, 2017
Summary
Researchers explored P16 expression as a biomarker for canine osteosarcoma (OSA) treatment response. While not statistically significant, a trend suggested P16 absence correlates with a shorter disease-free interval in dogs with OSA.
Area of Science:
- Veterinary Oncology
- Molecular Diagnostics
- Canine Cancer Research
Background:
- Osteosarcoma (OSA) is an aggressive bone cancer in large breed dogs, often with widespread metastases at diagnosis.
- Current treatments yield poor prognoses, with most dogs surviving less than a year post-diagnosis.
- Human OSA shares similarities with canine OSA, and P16 expression is linked to chemotherapy response.
Purpose of the Study:
- To investigate if P16 expression in canine osteosarcoma tissue predicts clinical outcomes.
- To identify a potential molecular marker for selecting canine OSA cases responsive to treatment.
Main Methods:
- Developed an antibody to detect canine P16.
- Created a canine osteosarcoma tissue microarray.
- Tested the association between P16 expression and clinical outcomes after amputation and chemotherapy.
Main Results:
- An antibody for canine P16 was successfully identified.
- A trend indicated that lack of P16 expression in canine OSA was associated with a shorter disease-free interval.
- Statistical significance was not reached in this study.
Conclusions:
- P16 is a potential molecular marker for canine osteosarcoma.
- Further larger studies are warranted to validate these findings.
- Identifying predictive markers is crucial for improving canine OSA treatment strategies.
