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Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report
Raya Mokhtari, Mozhdeh Sepaskhah1, Fatemeh Sari Aslani
1Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. sepaskhah_m@yahoo.com.
Dermatology Online Journal
|June 22, 2017
Summary
Autoimmune progesterone dermatitis (APD) is a rare allergy causing cyclical skin lesions. This case highlights APD
Area of Science:
- Dermatology
- Immunology
- Endocrinology
Background:
- Autoimmune progesterone dermatitis (APD) is a rare condition.
- It involves cyclical skin eruptions linked to the menstrual cycle.
- Manifestations range from eczema to erythema multiforme due to progesterone allergy.
Observation:
- A 46-year-old woman presented with recurrent, round erythematous plaques.
- Lesions appeared on the lower lip, forearms, and buttocks.
- Eruptions occurred cyclically, preceding menstruation by 3-4 days over 10 months.
Findings:
- Clinical history and physical examination suggested APD.
- A progesterone challenge test confirmed the diagnosis.
- Oral prednisolone (30 mg/day) before menstruation reduced eruption severity.
Implications:
- This case underscores the importance of considering APD in cyclical dermatoses.
- Progesterone allergy can present with diverse skin manifestations.
- While treatment can reduce severity, complete recurrence cessation remains a challenge.
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