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Related Experiment Videos

Effects of metoclopramide on detrusor function.

W C Mitchell, D D Venable

    The Journal of Urology
    |October 1, 1985
    PubMed
    Summary

    Metoclopramide significantly enhances bladder contractility in dogs, reducing capacity and residual volume. These effects on detrusor muscle function were comparable to bethanechol chloride.

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    Area of Science:

    • Pharmacology
    • Urology
    • Physiology

    Background:

    • Metoclopramide is a known gastrointestinal motility agent.
    • Its effects on the urinary system, specifically bladder function, are not well-documented.
    • Controlled studies on metoclopramide's impact on detrusor smooth muscle are lacking.

    Purpose of the Study:

    • To investigate the effects of metoclopramide on detrusor smooth muscle contractility.
    • To compare metoclopramide's effects with bethanechol chloride and a control substance.

    Main Methods:

    • A randomized, double-blind study was conducted using a canine model.
    • Metoclopramide, bethanechol chloride, and a control substance were administered.
    • Bladder capacity, detrusor peak voiding pressure, and post-void residual volume were measured.

    Main Results:

    • Metoclopramide significantly increased detrusor contractility.
    • This resulted in a decreased bladder capacity and increased detrusor peak voiding pressure.
    • A decrease in post-void residual volume was also observed with metoclopramide administration.
    • These effects were similar to those of parenteral bethanechol chloride.

    Conclusions:

    • Metoclopramide demonstrates significant effects on bladder function in a canine model.
    • The drug increases detrusor contractility, potentially benefiting conditions with impaired bladder emptying.
    • Further research is warranted to explore clinical applications in human urology.

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