Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

17.5K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.5K
Cellular Differentiation00:57

Cellular Differentiation

5.8K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.8K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.6K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.6K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.9K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.9K
Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

4.8K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RANSAC-based global 3DUS to CT/MR rigid registration using liver surface and vessels.

International journal of computer assisted radiology and surgery·2025
Same author

Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma.

Nature communications·2025
Same author

Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment.

Biomolecules·2025
Same author

MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling.

Cell metabolism·2025
Same author

Mitochondrial cristae: lung cancer metabolism architects.

Life metabolism·2025
Same author

A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite.

Analytical chemistry·2024

Related Experiment Video

Updated: Feb 28, 2026

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

1.1K

Mitochondrial dynamics coordinate cell differentiation.

Masafumi Noguchi1, Atsuko Kasahara2

  • 1Department of Biology, University of Padua, 35121 Padua, Italy.

Biochemical and Biophysical Research Communications
|June 22, 2017
PubMed
Summary

Mitochondria are crucial for cell differentiation and tissue development. This organelle regulates cell fate by coordinating signaling pathways, making it a potential target for therapeutic manipulation.

Keywords:
DifferentiationMitochondrial dynamicsNotch signallingStem cellWnt signallingYAP/TAZ signalling

More Related Videos

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

1.9K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

24.9K

Related Experiment Videos

Last Updated: Feb 28, 2026

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

1.1K
Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

1.9K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

24.9K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Mitochondrial Biology

Background:

  • Cell differentiation builds functional tissues.
  • Mitochondrial morphology, proteins, and functions change during differentiation.
  • Mitochondria are increasingly recognized for their roles beyond energy production.

Purpose of the Study:

  • To review the significance of mitochondrial dynamics and functions in tissue development.
  • To highlight mitochondria's role in cell differentiation and reprogramming.
  • To explore mitochondria as regulators of cell signaling pathways.

Main Methods:

  • Literature review of studies on mitochondrial dynamics and cell differentiation.
  • Analysis of signaling cascades involving mitochondria.
  • Synthesis of evidence on mitochondria's role in cell fate determination.

Main Results:

  • Mitochondrial dynamics and functions are integral to tissue development.
  • Mitochondria act as signaling hubs, coordinating pathways like Notch, Wnt, and YAP/TAZ.
  • Changes in mitochondrial properties correlate with cell differentiation states.

Conclusions:

  • Mitochondria are master regulators of cell differentiation.
  • Mitochondrial functions are critical for maintaining tissue homeostasis.
  • Targeting mitochondria offers potential for manipulating cell fates and reprogramming.