Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.6K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.6K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

5.1K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival rate and risk factors of implants in patients with head and neck neoplasms: a systematic review and meta-analysis.

BMC oral health·2026
Same author

Efficacy and Safety of Telitacicept in Posttransplant Recurrent IgA Nephropathy.

Kidney international reports·2026
Same author

Symmetry-driven directional selectivity of diffraction-free propagation in hyperbolic metasurfaces.

Applied optics·2026
Same author

Identification and clinical implications of immune-related hub genes in psoriasis.

PloS one·2026
Same author

Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma.

Journal of translational medicine·2026
Same author

Phase-velocity-reversed topological edge states and rainbows for field enhancement and radiation control.

Optics letters·2026
Same journal

Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.

Metabolic brain disease·2026
Same journal

Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.

Metabolic brain disease·2026
Same journal

Transthyretin at the crossroads of neurodegeneration: a silent guardian in Parkinson's disease.

Metabolic brain disease·2026
Same journal

Genetic and structural characterisation of alzheimer's disease associated variants in an Eastern Indian cohort.

Metabolic brain disease·2026
Same journal

Sex-specific gut microbiota and metabolite signatures in Parkinson's disease: implications for personalized therapeutics.

Metabolic brain disease·2026
Same journal

Genetic mutations and synaptic dysfunctions in social interaction disorders: insights from invertebrate models to humans.

Metabolic brain disease·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

9.3K

Insulin resistance in ischemic stroke.

Xiao-Ling Deng1, Zhou Liu2, Chuanling Wang3

  • 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, 442000, Hubei Province, People's Republic of China.

Metabolic Brain Disease
|June 22, 2017
PubMed
Summary
This summary is machine-generated.

Insulin resistance, where cells don't respond to insulin, is linked to ischemic stroke. Improving insulin resistance may help prevent or delay stroke.

Keywords:
AtherosclerosisInsulin resistanceIschemic strokeRisk factor

More Related Videos

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

943
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K

Related Experiment Videos

Last Updated: Feb 28, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

9.3K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

943
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K

Area of Science:

  • Metabolic disorders
  • Neurology
  • Cardiovascular science

Background:

  • Insulin resistance is a condition where cells inadequately respond to insulin.
  • Growing evidence highlights insulin resistance's significant role in ischemic stroke development.
  • Insulin resistance contributes to atherosclerosis, platelet dysfunction, and hemodynamic changes.

Purpose of the Study:

  • To elucidate the mechanisms by which insulin resistance contributes to ischemic stroke.
  • To review the role of insulin resistance in the pathogenesis of ischemic stroke.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of the impact of insulin resistance on atherosclerosis, platelet function, and hemodynamics.
  • Examination of insulin resistance's interaction with modifiable stroke risk factors.

Main Results:

  • Insulin resistance promotes advanced atherosclerotic changes.
  • It enhances platelet adhesion, activation, and aggregation, increasing stroke risk.
  • Insulin resistance contributes to hemodynamic disturbances and exacerbates other stroke risk factors.

Conclusions:

  • Insulin resistance is a key factor in the pathogenesis of ischemic stroke.
  • Targeting insulin resistance presents a potential therapeutic strategy for preventing or delaying ischemic stroke.