[Gerpes viruses and multiple sclerosis].

Area of Science:

• Neurology
• Vascular Medicine
• Pharmacology

Background:

• Cerebral venous dystonia involves impaired venous blood circulation and outflow.
• Microvascular dysfunction is a key component of these circulatory disturbances.
• Current treatments may not fully address the complex pathophysiology of cerebral venous disorders.

Purpose of the Study:

• To evaluate the efficacy of L-lysine aescinat in managing vascular and microvascular disorders associated with cerebral venous dystonia.
• To assess the impact of L-lysine aescinat on intracranial venous outflow and microcirculatory function.
• To determine the effects of L-lysine aescinat on autonomic responses in patients with cerebral venous dystonia.

Main Methods:

• A study involving 68 patients (25 male, 43 female, aged 25-56) diagnosed with cerebral venous dystonia.
• Cerebral hemodynamics assessed using comprehensive ultrasound examinations.
• Microcirculation functional status evaluated via laser Doppler flowmetry (LDF) before and after 10 days of L-lysine aescinat treatment.

Main Results:

• L-lysine aescinat significantly enhanced intracranial venous outflow.
• The treatment markedly improved microcirculation functioning without negatively altering normal patterns.
• Hemodynamic parameters showed improvement, indicating enhanced blood flow regulation.
• A notable modulating effect on autonomic responses was observed.

Conclusions:

• L-lysine aescinat demonstrates efficacy in improving venous outflow and microcirculation in patients with cerebral venous dystonia.
• The compound exhibits a beneficial modulating effect on autonomic responses, impacting both vagotonia and hypersympathicotonia.
• L-lysine aescinat can be recommended as part of a comprehensive treatment strategy for young and middle-aged adults experiencing cerebral venous blood circulation disturbances.