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[Melatonin in correction of REM-sleep behavior disorders in Parkinson's disease]
Е А Lyashenko1, O S Levin1, M G Poluektov2
1Russian Medical Academy of Postgraduate Education, Center for Movement Disorders, Moscow.
Abstract:
Objective - to estimate efficacy and safety of melatonin in REM-sleep behavior disorders (RBD) in patients with Parkinson's disease (PD).
Material And Methods:
We examined 60 patients with RBD and I-III stages of PD. Neuropsychological examination was performed before and after treatment. RBD was confirmed by polysomnography in 30 patients.
Results:
After the treatment with melatonin in dose of 3-6 mg for 4 weeks, 84% of patients reported reduction of RBD symptoms, daytime sleepiness, anxiety and depression.
Conclusion:
Melatonin can be used for RBD treatment in PD patients.
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