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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

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[Salivation after stroke].

Z A Zalyalova¹

¹Kazan State Medical University, Kazan.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|June 22, 2017

Summary

This summary is machine-generated.

Stroke-related excessive salivation (sialorrhea) impacts patients with dysphagia, causing significant distress and complications. Botulinum toxin injections offer an effective treatment for this challenging condition.

Keywords:

botulinum toxin dysphagia hypersalivation ptyalism salivary glands salivaton sialorrhea stroke

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Area of Science:

Neurology
Gastroenterology
Otolaryngology

Background:

Sialorrhea, or excessive salivation, is a common complication following stroke, often linked to neurogenic dysphagia, affecting 25-65% of patients.
This condition leads to difficulties in articulation, swallowing, and social interaction, significantly impacting quality of life and increasing caregiver burden.
Severe cases of sialorrhea can result in pulmonary aspiration, a life-threatening complication, with mortality rates of 20-24% in patients requiring tube feeding.

Purpose of the Study:

To investigate the causes and consequences of sialorrhea post-stroke.
To evaluate the effectiveness of botulinum toxin injections as a treatment for neurogenic sialorrhea.

Main Methods:

Review of existing literature on post-stroke sialorrhea and its management.
Analysis of treatment outcomes for botulinum toxin injections targeting salivary glands and cricopharyngeus muscle.

Main Results:

Sialorrhea in stroke patients stems from either excessive saliva production or impaired saliva utilization, frequently associated with dysphagia.
Botulinum toxin injections into the salivary glands and cricopharyngeus muscle demonstrate high efficacy in managing sialorrhea.
Treatment alleviates symptoms such as difficulty swallowing and articulation, reduces perioral irritation, and improves psychological well-being.

Conclusions:

Neurogenic sialorrhea is a significant post-stroke complication with multifactorial causes and serious consequences.
Botulinum toxin injections represent a highly effective therapeutic strategy for managing sialorrhea, improving patient quality of life and reducing healthcare burdens.