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[Myocardial injury associated with chronic hepatitis C: Clinical types and pathogenetic components]

L A Strizhakov1, S Yu Karpov1, V V Fomin1

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|June 22, 2017
PubMed

Insights

Chronic hepatitis C (CHC) can cause heart injury. This review explores how the hepatitis C virus directly and immunologically impacts the heart, leading to myocarditis and cardiomyopathies.

Area of Science:

  • Cardiology
  • Hepatology
  • Virology

Background:

  • Heart injury is a recognized extrahepatic manifestation of chronic hepatitis C (CHC).
  • Existing literature highlights a significant association between CHC and myocardial injury.
  • Understanding this link is crucial for comprehensive patient management.

Purpose of the Study:

  • To review and synthesize data on the relationship between CHC and myocardial injury.
  • To elucidate the pathogenetic mechanisms by which hepatitis C virus (HCV) affects the heart.
  • To discuss the role of viral and immunological factors in HCV-induced cardiac conditions.

Main Methods:

  • Literature review of Russian and international studies.
  • Analysis of pathogenetic pathways.
  • Synthesis of data on viral and immunological components.

Main Results:

  • Hepatitis C virus can directly impact myocardial tissue.
  • Immunological responses triggered by HCV contribute to cardiac damage.
  • These mechanisms can lead to the development of myocarditis and cardiomyopathies in CHC patients.

Conclusions:

  • CHC is associated with significant myocardial injury through direct viral effects and immune-mediated pathways.
  • HCV infection can induce inflammatory and degenerative heart conditions.
  • Further research into these mechanisms may inform therapeutic strategies for cardiac complications in CHC.

Keywords:
cardiomyopathychronic hepatitis Cmyocarditis

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