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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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[Vascular endothelial growth factors (VEGF): role in pathological processes]

Yu A Borzilova1, L A Boldyreva2, I V Shlyk2

  • 1Northwest State Medical University named after I.I. Mechnikov, Ministry of Health of the Russian Federation, 41 Kirochnaya St., St. Petersburg, 191015; Rostov State Medical University, Ministry of Health of the Russian Federation, 29 Nakhichevanskiy pereulok, Rostov-on-Don, Russian Federation, 344022.

Vestnik Oftalmologii
|June 22, 2017
PubMed

Insights

This study reviewed literature on vascular endothelial growth factors (VEGF) in the human body. Further research into diverse VEGF types and their roles in disease is recommended.

Area of Science:

  • Biomedical Sciences
  • Molecular Biology
  • Pathology

Background:

  • Vascular Endothelial Growth Factors (VEGF) are crucial signaling proteins.
  • VEGFs play significant roles in angiogenesis and vascular permeability.
  • Dysregulation of VEGF is implicated in various pathological conditions.

Purpose of the Study:

  • To analyze the existing Russian and foreign literature on VEGF.
  • To investigate the prevalence of different VEGF types across human tissues.
  • To understand the involvement of VEGF in pathological processes.

Main Methods:

  • Comprehensive literature review of scientific publications.
  • Analysis of data on VEGF distribution in various human body parts.
  • Examination of VEGF's role in disease pathogenesis.

Main Results:

  • Identified diverse VEGF expressions in different human anatomical regions.
  • Documented the association of VEGF with multiple pathological states.
  • Highlighted gaps in current knowledge regarding specific VEGF subtypes.

Conclusions:

  • Current literature provides a foundation for understanding VEGF roles.
  • Further investigation into the specific functions of various VEGF types is essential.
  • Elucidating the complex involvement of VEGF in pathology requires continued research.

Keywords:
VEGFdiabetes mellitusdiabetic retinopathyeyevascular endothelial growth factors

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