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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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[Personality traits as risk factors for the development of cognitive impairment and affective symptoms in patients with COVID-19].

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Related Experiment Video

Updated: Feb 28, 2026

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
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[Fabry's disease: Neurological disorders].

I V Damulin1

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|June 22, 2017
PubMed
Summary

Fabry

Area of Science:

  • Neurology
  • Genetics
  • Internal Medicine

Background:

  • Fabry's disease is a rare genetic disorder.
  • It affects multiple organ systems, including the nervous system.
  • Neurological manifestations are significant but often overlooked.

Purpose of the Study:

  • To review the pathogenesis and clinical features of Fabry's disease.
  • To highlight neurological involvement, including central and peripheral nervous system lesions.
  • To discuss diagnostic signs for early identification.

Main Methods:

  • Literature review on Fabry's disease.
  • Analysis of pathogenesis and clinical manifestations.
  • Synthesis of diagnostic criteria.
Keywords:
Fabry’s diseasediagnosisneurological disorderspathogenesistreatment

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Main Results:

  • Fabry's disease causes cardiovascular and kidney damage.
  • Central nervous system lesions, particularly cerebrovascular diseases, lead to disability.
  • Peripheral neuropathy involves small fibers and autonomic dysfunction.

Conclusions:

  • Fabry's disease presents with diverse neurological symptoms.
  • Cerebrovascular complications are a major cause of disability.
  • Recognizing specific signs is crucial for diagnosis.