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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Feb 28, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Stem cell-based tooth and periodontal regeneration.

L Hu1, Y Liu2, S Wang1,3

  • 1Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.

Oral Diseases
|June 22, 2017
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Summary

Stem cell-based tissue engineering offers new ways to regenerate teeth and periodontium. This review covers stem cell strategies and translational studies for dental repair.

Keywords:
periodontal regenerationstem cellstooth regeneration

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Stem Cell Biology

Background:

  • Tooth and periodontal regeneration remain significant challenges in dentistry.
  • Stem cell-based tissue engineering presents promising therapeutic strategies.
  • Various stem cell sources are being investigated for dental applications.

Purpose of the Study:

  • To review stem cell-based tissue engineering strategies for tooth and periodontal repair.
  • To discuss advances in dentin-pulp, whole tooth, bioroot, and periodontal regeneration.
  • To highlight translational investigations, including stem cell banking and clinical trials.

Main Methods:

  • Review of current literature on stem cell applications in dental regeneration.
  • Analysis of different stem cell types used for tooth and periodontal repair.
  • Examination of translational studies and clinical trial progress.

Main Results:

  • Substantial advances have been achieved in regenerating dental tissues and the periodontium using stem cells.
  • Multiple stem cell types, including DPSCs, PDLSCs, SCAPs, SHEDs, DFSCs, DESCs, BMMSCs, ADSCs, ESCs, and iPSCs, show potential.
  • Successful preclinical and clinical investigations are paving the way for therapeutic applications.

Conclusions:

  • Stem cell-based approaches are revolutionizing tooth and periodontal regeneration.
  • Continued research and translational studies are crucial for clinical success.
  • Tissue engineering holds significant promise for restoring dental and periodontal function.