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Changing trends in complications of chronic hepatitis C

Mei Lu1, Jia Li1, Loralee B Rupp2

  • 1Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.

Liver International : Official Journal of the International Association for the Study of the Liver
|June 22, 2017
PubMed

Insights

Chronic hepatitis C virus (HCV) complications like cirrhosis increased from 2006-2015. However, all-cause mortality in HCV patients has recently decreased, particularly after 2010.

Area of Science:

  • Hepatology and Viral Gastroenterology
  • Epidemiology and Public Health
  • Biostatistics and Health Informatics

Background:

  • Chronic hepatitis C virus (HCV) infection is associated with significant long-term health complications.
  • HCV-related complications, including cirrhosis and mortality, have shown increasing trends over the past decade.

Purpose of the Study:

  • To investigate epidemiological trends in HCV-related complications from 2006 to 2015.
  • To analyze the impact of demographic factors on the trends of cirrhosis, decompensated cirrhosis, and all-cause mortality in HCV-infected individuals.

Main Methods:

  • Utilized join-point regression modeling on data from the Chronic Hepatitis Cohort Study (CHeCS).
  • Analyzed trends in cirrhosis, decompensated cirrhosis, and all-cause mortality rates.
  • Adjusted analyses for race, sex, and age to identify demographic influences.

Main Results:

  • Prevalence of cirrhosis increased from 20.8% to 27.6% (aAPC 1.2%, p < .01) between 2006 and 2015.
  • All-cause mortality initially increased but showed a significant decrease after 2010 (aAPC -5.2%, p < .01).
  • Decompensated cirrhosis increased in patients aged 60+ (aAPC 1.5%, p = .023); disparities noted across racial/ethnic groups and sexes.

Conclusions:

  • Despite an overall rise in cirrhosis and mortality among HCV patients in the US over the last decade, recent years show a decline in all-cause mortality.
  • Demographic factors significantly influence the risk and trends of HCV complications, highlighting the need for targeted interventions.
Abstract

Keywords:
African AmericansAsian Americanscirrhosisdecompensated cirrhosis

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