Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methicillin-resistant Staphylococcus aureus in Dublin 1971-84.

M T Cafferkey, R Hone, D Coleman

    Lancet (London, England)
    |September 28, 1985
    PubMed
    Summary

    Methicillin-resistant Staphylococcus aureus (MRSA) became endemic in Dublin hospitals from 1976. Vancomycin was the most effective treatment for invasive MRSA infections, alongside surgical intervention and infection control measures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Staff experiences of percutaneous tracheostomy in intensive care: challenges, complications and potential solutions.

    Anaesthesia reports·2026
    Same author

    A Pelvic Osteotomy programme in a stand-alone orthopaedic centre: an early service evaluation.

    Irish medical journal·2023
    Same author

    Stylized versus voxel phantoms: quantification of internal organ chord length distances.

    Physics in medicine and biology·2023
    Same author

    Antibiotic susceptibility and molecular analysis of invasive Neisseria meningitidis recovered in the Republic of Ireland, 1996 to 2016.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2021
    Same author

    Menière's disease treated by grommet insertion.

    Annals of the Royal College of Surgeons of England·2019
    Same author

    Transfemoral Aortic Valve Replacement (TAVR): Is Incorporation of Interventional Radiologists into the Team Beneficial?

    Cardiovascular and interventional radiology·2019

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Hospital Epidemiology

    Background:

    • Methicillin-resistant Staphylococcus aureus (MRSA) emerged in Dublin hospitals between 1971-1975.
    • Gentamicin-resistant MRSA became endemic following the first recorded bacteraemia case in 1976.
    • MRSA bacteraemia peaked between 1979-1982, with ongoing clinical significance.

    Purpose of the Study:

    • To describe the epidemiology and characteristics of MRSA in Dublin hospitals.
    • To evaluate treatment efficacy and control measures for MRSA infections.
    • To investigate the molecular basis of MRSA resistance.

    Main Methods:

    • Retrospective analysis of MRSA infection and bacteraemia data.
    • Review of antimicrobial treatment regimens, focusing on vancomycin.

    Related Experiment Videos

  • Assessment of infection control strategies, including carriage elimination.
  • Molecular typing and phage-typing of MRSA isolates.
  • Analysis of gentamicin resistance mechanisms.

    • Main Results:

    • Gentamicin-resistant MRSA rapidly became endemic, peaking in 1979-82.
    • Vancomycin demonstrated high efficacy with minimal toxicity for invasive infections.
    • Surgical debridement and drainage were crucial adjuncts to antimicrobial therapy.
    • Infection control measures targeting carriage effectively reduced MRSA spread.
    • Molecular analysis identified two distinct MRSA phenotypes; gentamicin resistance was chromosomally encoded.

    Conclusions:

    • MRSA, particularly gentamicin-resistant strains, posed a significant and persistent challenge in Dublin hospitals.
    • Vancomycin, combined with surgical intervention and robust infection control, represented the optimal management strategy.
    • Understanding the molecular epidemiology and resistance mechanisms is vital for controlling MRSA outbreaks.