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Updated: Feb 28, 2026
06:51
Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
Published on: April 29, 2016
22.5K
T-Regulating Hair Follicle Stem Cells
Maria Maryanovich1, Paul S Frenette2
1Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Immunity
|June 22, 2017
Summary
Regulatory T (Treg) cells modulate inflammation and maintain stem cells. Skin-resident Treg cells in the hair follicle stem cell niche control hair regeneration.
Area of Science:
- Immunology
- Dermatology
- Stem Cell Biology
Background:
- Regulatory T (Treg) cells are crucial for immune homeostasis and inflammation control.
- The role of Treg cells in tissue regeneration and stem cell maintenance is an emerging area of research.
Purpose of the Study:
- To investigate the function of skin-resident Treg cells in the hair follicle stem cell (HFSC) niche.
- To determine the role of Treg cells in HFSC-mediated hair regeneration.
Main Methods:
- Utilized mouse models to study Treg cell localization and function within the hair follicle.
- Employed lineage tracing and gene expression analysis to assess HFSC activity and regeneration.
Main Results:
- Demonstrated that Foxp3+ Treg cells preferentially accumulate in the HFSC niche.
- Showed that Treg cells directly interact with HFSCs and regulate their behavior.
- Found that Treg cells are essential for efficient HFSC-mediated hair regeneration.
Conclusions:
- Skin-resident Treg cells play a previously unrecognized role in stem cell maintenance.
- Treg cells are key regulators of hair follicle stem cell function and hair regeneration.
- These findings open new avenues for therapeutic strategies targeting hair loss and other regenerative processes.
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