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Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders

Morten Jacobsen¹, Arvid Jensen², Guttorm Breivik Storvestre²

¹University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern 0318, Oslo. Norway.

Current Radiopharmaceuticals

|June 23, 2017

Abstract

Background And Objective:

In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence.

Methods:

Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence.

Results:

All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings.

Conclusion:

Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion of brain tissue. We discuss our findings in the light of other possible pathophysiological mechanisms.

Keywords:

SPECT Schizophrenia spectrum disorder brain perfusion forensic psychiatry.violence

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