Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Predicting Risk of Plasmodium Vivax Microscopy-Detected Episodes Using Serological Markers in Patients With Plasmodium falciparum Malaria: A Multicountry Diagnostic Performance Evaluation.

The Journal of infectious diseases·2026

Same author

Mortality among healthcare workers in Indonesia during 18 months of COVID-19.

PLOS global public health·2023

Same author

The global burden of Plasmodium vivax malaria is obscure and insidious.

PLoS medicine·2021

Same author

Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia <i>Ex Vivo</i>: Potentials and Pitfalls.

Antimicrobial agents and chemotherapy·2020

Same journal

Multinational cohort study of health perception mismatch trajectories and risks of cognitive decline, depression, and mortality.

BMC public health·2026

Same journal

The association between heat waves and pregnancy outcome among women undergoing assisted reproductive technology in Sichuan, China.

BMC public health·2026

Same journal

Driving NCD screening at scale: outcomes of a digital, CHW-led hypertension surveillance program in rural Rwanda.

BMC public health·2026

Same journal

Correct knowledge of tuberculosis as a determinant of risk perception among patients with type 2 diabetes mellitus in rural Karnataka.

BMC public health·2026

Same journal

Urban-rural dichotomy of emergency medical service demand: spatiotemporal patterns and heterogeneous driving mechanisms.

BMC public health·2026

Same journal

Association between household food insecurity and quality of life: a longitudinal study in Northeast Brazil, 2014-2019.

BMC public health·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Malaria control by commodities without practical malariology.

J Kevin Baird^1,2

¹Eijkman-Oxford Clinical Research Unit, Jalan Diponegoro No.69, Jakarta, 10430, Indonesia. kevin.baird@ndm.ox.ac.uk.

BMC Public Health

|June 23, 2017

Summary

This summary is machine-generated.

Malaria control shifted from environmental modification to commodity-based strategies. Over-reliance on commodities risks resurgence, prompting a return to practical malariology for prevention.

Keywords:

Control History Malaria Malariology Prevention Species sanitation Strategy

More Related Videos

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

A Simple Chelex Protocol for DNA Extraction from Anopheles spp.

A Simple Chelex Protocol for DNA Extraction from Anopheles spp.

Published on: January 9, 2013

Related Experiment Videos

Last Updated: Jun 16, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

A Simple Chelex Protocol for DNA Extraction from Anopheles spp.

A Simple Chelex Protocol for DNA Extraction from Anopheles spp.

Published on: January 9, 2013

Area of Science:

Public Health
Tropical Medicine
Vector-Borne Diseases

Background:

Malaria control has evolved significantly, particularly after 1945 with the introduction of DDT.
Early 20th-century malariology focused on environmental modifications to target Anopheles mosquito vectors.
This practical approach achieved substantial reductions in malaria morbidity and mortality.

Observation:

The widespread use of DDT led to mosquito resistance and environmental concerns, causing the collapse of eradication campaigns by 1970.
Post-DDT strategies shifted to synthetic antimalarial drugs, which later faced parasite resistance, leading to malaria resurgence.
Current strategies since 2005 rely heavily on commodities like diagnostics, artemisinin-based treatments, and insecticide-treated nets.

Findings:

Contemporary malaria control primarily mitigates infection consequences rather than focusing on prevention through environmental manipulation.
The current commodity-driven strategy lacks the integrated, specialized knowledge of historical practical malariology.
Over-reliance on commodities presents inherent risks and limitations in sustained malaria control.

Implications:

A strategic re-evaluation is needed to incorporate proven, preventative methods of practical malariology.
Integrating historical knowledge with modern tools could enhance long-term malaria control effectiveness.
Considering a balanced approach combining commodity-based interventions with environmental strategies is crucial for future malaria eradication efforts.