Related Experiment Video
Updated: Feb 28, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53: master of life, death, and the epigenome
1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Abstract:
Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. In this issue of Genes & Development, Tovy and colleagues (pp. 959-972) report that, in naïve mouse embryonic stem cells (ESCs), p53 controls DNA methylation homeostasis by regulating the expression of key counteracting components of the DNA methylation machinery. Their findings indicate that p53 may exert its "guardian of genome" duties at least in part via safeguarding the epigenome of ESCs.
Related Concept Videos
Abnormal Proliferation
Negative Regulator Molecules
DNA Damage Can Stall the Cell Cycle
DNA Damage can Stall the Cell Cycle
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation

