Goal-Directed Perfusion Methodology for Determining Oxygenator Performance during Clinical Cardiopulmonary Bypass.

Area of Science:

• Cardiovascular Surgery
• Biomedical Engineering
• Medical Devices

Background:

• New oxygenator designs integrate arterial line filtration, potentially impacting gas exchange.
• Evaluating the clinical performance of these integrated filtration systems is crucial.

Purpose of the Study:

• To compare the gas exchange performance and clinical outcomes of three different oxygenator models during cardiopulmonary bypass (CPB).
• To assess the effect of integrated versus external arterial line filtration on patient parameters.

Main Methods:

• A prospective clinical study involving 60 adult cardiac surgery patients.
• Patients were divided into three groups based on oxygenator type: Terumo SX18 (integrated filter), Terumo FX15 (external filter), and LivaNova Inspire6F (integrated filter).
• Standardized goal-directed perfusion and patient management protocols were applied.

Main Results:

• The LivaNova Inspire6F required lower fraction of inspired oxygen compared to both Terumo models.
• The Terumo FX15 showed slightly higher arterial oxygen content and delivery.
• Postoperative transfusion rates were higher in the Terumo SX18 group compared to the other two groups.

Conclusions:

• The Terumo SX18 oxygenator demonstrated comparable gas exchange performance and hemodilution to newer generation oxygenators.
• Integrated arterial line filtration in oxygenators did not lead to significant differences in postoperative morbidity.