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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
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Evaluation of Microorganisms Causing Ventilator-Associated Pneumonia in a Pediatric Intensive Care Unit

Ayse Betul Ergul1, Serife Cetin2, Yasemin Ay Altintop3

  • 1Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.

The Eurasian Journal of Medicine
|June 23, 2017
PubMed
Abstract

Insights

This study identified common bacteria causing ventilator-associated pneumonia (VAP) in a pediatric ICU. Colistin showed high susceptibility, but resistance in Pseudomonas aeruginosa highlights the need for local antibiotic resistance monitoring.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Ventilator-associated pneumonia (VAP) is a significant concern in pediatric intensive care units (PICUs).
  • Understanding the causative microorganisms and their antibiotic susceptibility is crucial for effective treatment.

Purpose of the Study:

  • To identify the microorganisms responsible for VAP in a PICU.
  • To assess the antibiotic resistance and susceptibility patterns of these VAP-causing pathogens.

Main Methods:

  • Retrospective analysis of VAP cases in a PICU from January 2014 to June 2016.
  • Identification and antibiotic susceptibility testing of isolated microorganisms from VAP patients.

Main Results:

  • 44 VAP patients were included; 75% had underlying chronic diseases and 75% mortality.
  • Gram-negative bacteria predominated (96%), with Pseudomonas aeruginosa (32%), Klebsiella pneumoniae (24%), and Acinetobacter baumannii (22%) being most common.
  • High susceptibility was observed for colistin (92.6%), piperacillin-tazobactam (71.4%), amikacin (65.2%), and gentamicin (52.2%).

Conclusions:

  • Local antibiotic resistance patterns are essential for guiding empirical antibiotic therapy in VAP.
  • Colistin remains effective against most VAP pathogens, but monitoring resistance in P. aeruginosa is necessary.
Keywords:
Ventilator-associated pneumoniaantibioticmicroorganismpediatric intensive care

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