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Updated: Feb 28, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
Anne M Dickinson1, Jean Norden1, Shuang Li2
1Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Abstract:
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
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