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Pre-rheumatoid arthritis and its prevention.
Binoy J Paul1, Hemanth Illath Kandy1, Vinod Krishnan1
1Department of Internal Medicine, KMCT Medical College, Kerala, India.
European Journal of Rheumatology
|June 23, 2017
Summary
Pre-rheumatoid arthritis (pre-RA) is the preclinical stage before rheumatoid arthritis (RA) develops. Understanding pre-RA can help create early detection programs and identify risk factors for prevention.
Area of Science:
- Rheumatology
- Immunology
- Epidemiology
Background:
- Pre-rheumatoid arthritis (pre-RA) represents the preclinical phase of rheumatoid arthritis (RA).
- This stage involves the interplay of genetic and environmental factors, leading to autoantibody development and early, often nonspecific, joint symptoms.
- Understanding pre-RA is crucial for early RA detection and intervention.
Purpose of the Study:
- To elucidate the characteristics and significance of the pre-rheumatoid arthritis (pre-RA) stage.
- To highlight the potential for early detection and prevention strategies for rheumatoid arthritis (RA).
Main Methods:
- Review of existing literature on the preclinical phase of rheumatoid arthritis.
- Analysis of risk factors contributing to the development of pre-RA and subsequent RA.
Main Results:
- Pre-RA is characterized by genetic and environmental risk factor interactions, autoantibody formation, and nonspecific joint symptoms.
- Key risk factors include smoking, periodontitis, obesity, viral infections, and hormonal/dietary influences.
- Early identification of these factors is vital for RA prevention.
Conclusions:
- A comprehensive understanding of pre-RA is essential for developing effective screening and prevention programs for rheumatoid arthritis.
- Modifying identified risk factors in susceptible populations can potentially prevent the onset of RA.
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