Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Positive vs. negative schizophrenia: a critical evaluation.

N C Andreasen

    Schizophrenia Bulletin
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction.

    Molecular psychiatry·2017
    Same author

    Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.

    Neuroscience and biobehavioral reviews·2013
    Same author

    MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse.

    Psychological medicine·2012
    Same author

    Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes.

    Molecular psychiatry·2011
    Same author

    Auditory and visual attention assessed with PET.

    Human brain mapping·2010
    Same author

    Cognitive deficits in recent-onset and chronic schizophrenia.

    Journal of psychiatric research·2009

    The positive versus negative symptom distinction in schizophrenia requires clarification. This review examines its application to disease subtypes, proposing modifications for better etiological specificity.

    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Neuroscience

    Background:

    • The positive versus negative symptom distinction is frequently discussed in schizophrenia research.
    • However, the precise referent of this distinction (symptoms, syndromes, or diseases) is often unclear.
    • Etiological specificity differentiates diseases from nonspecific symptoms and syndromes.

    Purpose of the Study:

    • To critically review the evidence for using the positive/negative distinction to subtype schizophrenic diseases.
    • To propose modifications to the hypothesis for improved etiological clarity.
    • To enhance the understanding of disease heterogeneity in schizophrenia.

    Main Methods:

    • Literature review and critical analysis of existing research.
    • Examination of the etiological and pathophysiological basis of symptom clusters.

    Related Experiment Videos

  • Theoretical synthesis and proposal of revised subtyping models.

    • Main Results:

    • The positive/negative distinction is inconsistently applied, lacking etiological specificity when referring to symptoms or syndromes.
    • Evidence for discrete disease subtypes based solely on this distinction is limited.
    • Current approaches may oversimplify the complex pathophysiology of schizophrenia.

    Conclusions:

    • Refining the positive/negative distinction is crucial for identifying distinct pathophysiological subtypes of schizophrenia.
    • Modifications are needed to align subtyping with specific etiologies.
    • Future research should focus on biologically grounded subtypes beyond simple symptom dichotomies.