Related Experiment Video

Updated: Feb 28, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.6K

Cardiovascular Autonomic Neuropathy Is an Independent Risk Factor for Left Ventricular Diastolic Dysfunction in

Jiewen Jin1, Weimin Wang1, Liangying Zhu1

  • 1Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, China.

Biomed Research International
|June 23, 2017
PubMed

Insights

Cardiovascular autonomic neuropathy (CAN) is an independent risk factor for left ventricular diastolic dysfunction (LVDD) in type 2 diabetes patients. Early detection and treatment of CAN are crucial for preventing LVDD.

Area of Science:

  • Cardiology
  • Diabetology
  • Autonomic Nervous System Research

Background:

  • Cardiovascular autonomic neuropathy (CAN) is a common complication in type 2 diabetes.
  • Left ventricular diastolic dysfunction (LVDD) is associated with increased cardiovascular risk in diabetic patients.
  • The relationship between CAN and LVDD in type 2 diabetes requires further elucidation.

Purpose of the Study:

  • To investigate the association between cardiovascular autonomic neuropathy (CAN) and left ventricular diastolic dysfunction (LVDD) in patients with type 2 diabetes.
  • To determine if CAN is an independent risk factor for LVDD in this population.

Main Methods:

  • 315 type 2 diabetes patients were assessed for CAN using cardiovascular autonomic reflex tests, categorizing them into no CAN (NCAN), possible CAN (PCAN), and definite CAN (DCAN).
  • Left ventricular diastolic function was evaluated using tissue Doppler imaging echocardiography.
  • Multivariate regression analysis was employed to identify independent risk factors for LVDD.

Main Results:

  • The prevalence of LVDD increased significantly with the severity of CAN (39.4% in NCAN, 45.3% in PCAN, 68.0% in DCAN; P = 0.001).
  • Patients with definite CAN exhibited higher E/e' ratios (indicating elevated filling pressures) and impaired e' (diastolic performance) compared to those without CAN.
  • CAN was identified as an independent risk factor for LVDD (OR = 1.628, P = 0.009).

Conclusions:

  • Cardiovascular autonomic neuropathy is a significant independent risk marker for left ventricular diastolic dysfunction in type 2 diabetes.
  • Prompt diagnosis and management of CAN are recommended to prevent the development of LVDD and mitigate cardiovascular risk in diabetic patients.
Abstract

More Related Videos

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.5K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

692

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
667
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.2K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
531
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
700