RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS

Area of Science:

• Veterinary Virology
• Pharmacology
• Hepatology

Background:

• Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a severe disease with high mortality.
• Current treatments for DVH are lacking, necessitating the exploration of novel therapeutic agents.

Purpose of the Study:

• To evaluate the efficacy of Raw Rehmannia Radix Polysaccharide (RRRP) and other plant-derived polysaccharides against DHAV.
• To determine the protective effects of RRRP on liver pathology and oxidative stress in DHAV-infected ducks.

Main Methods:

• In vitro and in vivo experiments were conducted using RRRP, Lycii Fructus polysaccharides, and Astragalus Radix polysaccharides.
• Key indicators assessed included mortality rates, liver changes, lesion scoring, and oxidative stress markers (SOD, GSH-Px, CAT, NOS, MDA).

Main Results:

• RRRP demonstrated the highest efficacy, reducing mortality by approximately 20% and significantly alleviating liver pathological changes.
• RRRP treatment led to lower liver lesion scores and normalized hepatic injury markers compared to the viral control group.
• RRRP significantly reduced peroxidative injury by increasing antioxidant enzyme levels (SOD, GSH-Px, CAT) and decreasing pro-oxidant markers (NOS, MDA).

Conclusions:

• RRRP is the most effective agent against DHAV among those tested, offering significant protection against mortality and liver injury.
• RRRP's antiviral and anti-peroxidative properties provide a basis for developing new therapeutic strategies for viral hepatitis.
• The study highlights RRRP as a potential therapeutic candidate for DVH and possibly human hepatitis A virus infections.