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Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
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NEUROPROTECTIVE EFFECT OF TERMINALIA CHEBULA EXTRACTS AND ELLAGIC ACID IN PC12 CELLS.

Yuh-Chiang Shen1,2,3, Chi-Wen Juan4,5, Che-San Lin6

  • 1National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C.).

African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM
|June 23, 2017
PubMed
Summary

Terminalia chebula extracts and ellagic acid show neuroprotective effects against Alzheimer's disease by reducing oxidative stress and calcium influx in PC12 cells.

Keywords:
Neuroprotective effectTerminalia chebula; ellagic acidbeta-amyloid

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Phytochemistry

Background:

  • Alzheimer's disease (AD) is a prevalent neurodegenerative disorder in the elderly.
  • Beta-amyloid (Aβ) peptide accumulation is a key pathological hallmark of AD.
  • PC12 cell line is a widely used model for studying neuronal damage and neuroprotection.

Purpose of the Study:

  • To investigate the neuroprotective potential of Terminalia chebula (T. chebula) extracts and ellagic acid.
  • To elucidate the underlying mechanisms of neuroprotection against Aβ-induced toxicity.
  • To evaluate the efficacy of T. chebula and ellagic acid in a cellular model of AD.

Main Methods:

  • Preparation of T. chebula extracts using methanol, water, and ethanol.
  • Isolation of ellagic acid.
  • Assessment of cell viability and toxicity in PC12 cells exposed to Aβ25-35.
  • Measurement of intracellular reactive oxygen species (ROS) and calcium levels.

Main Results:

  • Methanolic and water extracts of T. chebula, along with ellagic acid, demonstrated significant neuroprotective activity against Aβ25-35-induced PC12 cell damage.
  • Ellagic acid also showed partial neuroprotection against hydrogen peroxide (H2O2)-induced cell damage.
  • Neuroprotection was achieved by inhibiting ROS production and reducing intracellular calcium influx.

Conclusions:

  • T. chebula is a promising plant-based source for AD therapeutics.
  • Ellagic acid is a key active component contributing to the neuroprotective effects of T. chebula.
  • Further in vivo studies are warranted to confirm the efficacy and mechanisms of T. chebula extracts and ellagic acid in AD treatment.